IV Alpha Lipoic Acid

What is IV ALA Therapy?

IV ALA therapy bypasses absorption and delivers ALA directly into the bloodstream.

Is IV Alpha Lipoic Acid Therapy Safe?

We’ve administered thousands of IV Alpha Lipoic Acid treatments safely at the clinic. Preparation of the IV is important as alpha lipoic acid is destroyed by light so it is delivered with protection of the IV bag from light exposure.

Health Canada prohibits advertising of IV medicines associating them with any disease, health condition or showing the studies of these medicines. Please give us a call or email for further information.

Health Canada prohibits advertising of IV medicines associating them with any disease, health condition or showing the studies of these medicines. Please give us a call or email for further information.

Book an appointment or call our office today at (204) 775-4539 to discuss potential treatment options.

References

Al-Majed, A. A., Gdo, A. M., Al-Shabanah, O. A., et al. (2002) Alpha-lipoic acid ameliorates myocardial toxicity induced by doxorubicin. Pharmacol Res. 46(6):499–503.

Balachandar, A. V., Malarkodi, K. P., and Varalakshmi, P. (2003) Protective role of DLalpha-lipoic acid against adriamycin-induced cardiac lipid peroxidation. Hum Exp Toxicol. 22(5):249–54.

Berkson, B. M., Rubin, D. M., and Berkson, A. J. (2006) The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol. Integr Cancer Ther. 5(1):83–9.

Berkson, B. M., Rubin, D. M., and Berkson, A. J. (2009) Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther. 8(4):416–22.

Choi, S. Y., Yu, J. H., and Kim, H. (2009) Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells. Ann N Y Acad Sci.1171:149–55.

Dadhania, V. P., Tripathi, D. N., Vikram, A., et al. (2010) Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine. Chem Biol Interact. 183(1):85–97.

de Jonge, M. J. A. and Verweij, J. (2006) Renal toxicities of chemotherapy. Semin Oncol. 33:68–73.

Dovinova, I., Novotny, L., Rauko, P., et al. (1999) Combined effect of lipoic acid and doxorubicin in murine leukemia. Neoplasma46:237–41.

Finkel, K. W. and Foringer, J. R. (2007) Renal disease in patients with cancer. Nat Clin Pract Nephrol3:669–78.

Flier, J., Van Muiswinkel, F. L., Jongenelen, C. A., et al. (2002) The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells. Free Radic Res36:695–9.

Gedlicka, C., Scheithauer, W., Schull, B., a et al. (2002) Effective treatment of oxaliplatin-induced cumulative polyneuropathy with alpha-lipoic acid. J Clin Oncol. 20:3359–61.

Gedlicka, C., Kornek, G. V., Schmid, K., et al. (2003) Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid. Ann Oncol. 14:339–40.

Humphreys, B. D., Soiffer, R. J., and Magee, C. C. (2005) Renal failure associated with cancer and its treatment: An update. J Am Soc Nephrol. 16:151–61.

Lameire, N. H., Flombaum, C. D., Moreau, D., et al. (2005) Acute renal failure in cancer patients. Ann Med. 37:13–25.

Mantovani, G., Macciò,A.,Melis, G., et al. (2000) Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine. Int J Cancer. 86:842–7.

Malarkodi, K. P., Balanchandar, A. V., and Varlakshmi. P. (2003a) The influence of lipoic acid on adriamycin induced nephrotoxicity in rats. Mol Cell Biochem. 247:15–22.

Malarkodi, K. P., Balanchandar, A. V., and Varlakshmi. P. (2003b) The influence of lipoic acid on adriamycin-induced hyper-lipidemic nephrotoxicity in rats. Mol Cell Biochem. 247:139–45.

Malarkodi, K. P., Balanchandar, A. V., and Varlakshmi. P. (2003c) Protective effect of lipoic acid on adriamycin-induced lipid peroxidation in rat kidney. Mol Cell Biochem. 247:9–13.

Malarkodi, K. P., Balanchandar, A. V., Sivaprasad, R., et al. (2003d) Prophylactic effect of lipoic acid against adriamycin-induced peroxidative damages in rat kidney. Ren Fail25:367–77.

Melli, G., Taiana, M., Camozzi, F., et al. (2008) Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. Exp Neurol. 214(2):276–84.

Moungjaroen, J., Nimmannit, U., Callery, P. S., et al. (2006) Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther319:1062–9.

Murugavel, P. and Pari, L. (2004) Attenuation of chloroquine-induced renal damage by alpha-lipoic acid: possible antioxidant mechanism. Ren Fail. 26(5):517–24.

Pack, R.A., Hardy, K., Madigan, M. C., et al. (2002) Differential effects of the antioxidant alpha-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells. Mol Immunol. 38:733–45.

Pai, V. B. and Nahata, M. C. (2000) Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf. 22(4):263–302.

Perazella, M. A. and Moeckel, G. W. (2010) Nephrotoxicity from chemotherapeutic agents: Clinical manifestations, pathobiology, and prevention/therapy. Semin Nephrol. 30:570–81.

Shi, D. Y., Liu, H. L., Stern, J. S., et al. (2008) Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS Lett. 582:1667–71.

Stein, A., Voigt, W., and Jordan, K. (2010) Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol. 2(1):51–63.

Wenzel, U., Nickel, A., and Daniel, H. (2005) alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation. Apoptosis. 10(2):359–68.